Stat of the week -- Twenty players have missed a combined 104 games this season due to injuries.
The game plan -- Once again, the Colts will attempt to get off to a strong start in Kansas City.
Indianapolis did a better job of starting a game last week against the Texans, but sluggish starts have been one of the Colts' biggest issues in road games.
The Colts had only one offensive turnover in the Houston loss, but it was a big one (fumble on the goal line). Indianapolis has to hold on to the football and score touchdowns in the red zone.
Defensively, control the run. And be aggressive up front. Kansas City has had issues holding on to the football. The Colts have to be able to force turnovers and control the game.
Key matchups -- Colts QB Andrew Luck vs. Chiefs pass defense. Indianapolis' offense is ranked ninth in the NFL, averaging 374.7 yards per game. The Colts' passing game is ranked eighth (267.8). Kansas City's pass defense is ranked seventh overall in the league, allowing 215.6 yards per game.
Chiefs QB Brady Quinn vs. Colts OLBs Dwight Freeney/Robert Mathis. Quinn is hurt going on, still suffering the effects of a rib injury, has been sacked 16 times this season. As a team, Kansas City has allowed 35 sacks. Freeney and Mathis rank No. 1 and No.2 all-time in franchise history in sacks.
Colts WR Reggie Wayne vs. Chiefs secondary. Wayne has caught a team-high 97 passes this season for 1,234 yards and four touchdowns. LCB Brandon Flowers has a team-high three interceptions for Kansas City. The Chiefs have allowed 25 touchdown passes this season.