Jaguars QB Blaine Gabbert vs. the Colts' pass rush. Indianapolis didn't do a bad overall job against Gabbert earlier in the season, although there were some crucial breakdowns in the second half of that game that allowed the rookie signal caller to break free of the pocket and make some plays downfield. That can't happen on Sunday.
Colts run defense vs. Jaguars RB Maurice Jones-Drew. Jones-Drew is considered to be the best running back that Indianapolis' defense faces on a regular basis. He has been tough for the Colts to stop completely. They've slowed him down some on occasion, but Indianapolis -- who came very close to drafting Jones-Drew in 2006 and teaming him with RB Joseph Addai -- has yet to completely shut him down.